Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis.

Endoplasmic reticulum stress contributes to Helicobacter pylori VacA-induced apoptosis.

Vacuolating cytotoxin A (VacA) is one of the important virulence factors produced by H. pylori. VacA induces apoptotic cell death, which is potentiated by ammonia. VacA also causes cell death by mitochondrial damage, via signaling pathways that are not fully defined. Our aim was to determine whether...

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Bibliographic Details
Main Authors: Yuko Akazawa, Hajime Isomoto, Kayoko Matsushima, Tsutomu Kanda, Hitomi Minami, Naoyuki Yamaghchi, Naota Taura, Ken Shiozawa, Ken Ohnita, Fuminao Takeshima, Masayuki Nakano, Joel Moss, Toshiya Hirayama, Kazuhiko Nakao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3862672?pdf=render

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http://europepmc.org/articles/PMC3862672?pdf=render

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