Evaluating Blood Parameters, P53, and IL6 in Personnel of Copper Complex: A Comparison with Control Group

• Main Authors: Hadis Ahmadiraad, Mina Hemmati, Mehdi Mahmodi, Ahmadreza Sayadi Anari, Mohammadreza Mirzaee, Alireza Khoshdel, Maryam Amiri, Fahimmeh MohammadainShahrbabaki, Mohammadreza Hajizade
• Format: Article
• Language: fas
• Published: Fasa University of Medical Sciences 2016-03-01
• Series: Journal of Fasa University of Medical Sciences
• Subjects: Industrial pollution; Trace elements; IL6; P53
• Online Access: http://journal.fums.ac.ir/browse.php?a_code=A-10-1052-1&slc_lang=en&sid=1

Background & Objectives: Industrial pollution including trace elements is the ability to exert many biological effects such as cancer and inflammatory diseases on humans. Therefore, in this study, some of the inflammation and cancer awareness factors such as P53 and IL6 and some blood indices are examined along with trace elements to which people are normally exposed. Materials & Methods: The population includes 45 workers subjected to trace elements who are studied in comparison with the control group with some biochemical parameters such as WBC, RBC, and CRP. In addition, gene expressions of p53 and IL6 are measured by Real time PCR technique. Results: The results show that the gene expressions of IL6 and P53 increases significantly (P –Value p53=0.00, IL6=0.0037). Furthermore, the number of red and white blood cells demonstrate a substantial upsurge. The level of liver enzymes of ALT and AST grows. Additionally, ALP reduces and CRP is negative in all the subjects. (P = 0.001). Conclusion: The results confirm that industrial pollution is able to induce some changes in gene expressions of P53, IL6, and some blood parameters. It may create serious risks for people who will be exposed to pollution in the future.