A multidimensional systems biology analysis of cellular senescence in aging and disease

A multidimensional systems biology analysis of cellular senescence in aging and disease

Abstract Background Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking....

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Bibliographic Details
Main Authors: Roberto A. Avelar, Javier Gómez Ortega, Robi Tacutu, Eleanor J. Tyler, Dominic Bennett, Paolo Binetti, Arie Budovsky, Kasit Chatsirisupachai, Emily Johnson, Alex Murray, Samuel Shields, Daniela Tejada-Martinez, Daniel Thornton, Vadim E. Fraifeld, Cleo L. Bishop, João Pedro de Magalhães
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Genome Biology
Subjects:
Biogerontology
Cancer
Genetics
Longevity
Transcriptome
Online Access:http://link.springer.com/article/10.1186/s13059-020-01990-9

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