Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ12,14-prostaglandin J2-like compounds (deoxy-J2-isoprostanes) in vivo1

Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ12,14-prostaglandin J2-like compounds (deoxy-J2-isoprostanes) in vivo1

15-Deoxy-Δ12,14-prostaglandin J2 (15-d-PGJ2) is a reactive cyclopentenone eicosanoid generated from the dehydration of cyclooxygenase-derived prostaglandin D2 (PGD2). This compound possesses an α,β-unsaturated carbonyl moiety that can readily adduct thiol-containing biomolecules such as glutathione...

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Bibliographic Details
Main Authors: Klarissa D. Hardy, Brian E. Cox, Ginger L. Milne, Huiyong Yin, II L. Jackson Roberts
Format: Article
Language:English
Published: Elsevier 2011-01-01
Series:Journal of Lipid Research
Subjects:
15-d-PGJ2
cyclopentenone eicosanoid
lipid peroxidation
oxidant stress
isoprostane
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520405024

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http://www.sciencedirect.com/science/article/pii/S0022227520405024

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