Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival

Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival

<p>Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approache...

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Main Author: Howard H. Chen, Hushan Yuan, Lee Josephson, David E. Sosnovik
Format: Article
Language:English
Published: Ivyspring International Publisher 2012-01-01
Series:Theranostics
Online Access:http://www.thno.org/v02p0148.htm
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spelling doaj-7b82925f8d1145f6aeb61ef889e068c72020-11-24T23:15:57ZengIvyspring International PublisherTheranostics1838-76402012-01-0121148155Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and SurvivalHoward H. Chen, Hushan Yuan, Lee Josephson, David E. Sosnovik<p>Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approaches used to date to perform molecular imaging of these important targets. We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach.</p>http://www.thno.org/v02p0148.htm
collection DOAJ
language English
format Article
sources DOAJ
author Howard H. Chen, Hushan Yuan, Lee Josephson, David E. Sosnovik
spellingShingle Howard H. Chen, Hushan Yuan, Lee Josephson, David E. Sosnovik
Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
Theranostics
author_facet Howard H. Chen, Hushan Yuan, Lee Josephson, David E. Sosnovik
author_sort Howard H. Chen, Hushan Yuan, Lee Josephson, David E. Sosnovik
title Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
title_short Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
title_full Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
title_fullStr Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
title_full_unstemmed Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival
title_sort theranostic imaging of the kinases and proteases that modulate cell death and survival
publisher Ivyspring International Publisher
series Theranostics
issn 1838-7640
publishDate 2012-01-01
description <p>Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approaches used to date to perform molecular imaging of these important targets. We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach.</p>
url http://www.thno.org/v02p0148.htm
work_keys_str_mv AT howardhchenhushanyuanleejosephsondavidesosnovik theranosticimagingofthekinasesandproteasesthatmodulatecelldeathandsurvival
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