Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells

Numb is an intracellular protein with multiple functions. The two prevalent isoforms, Numb p66 and Numb p72, are regulators of differentiation and proliferation in neuronal development. Additionally, Numb functions as cell fate determinant of stem cells and cancer stem cells and its abnormal express...

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Bibliographic Details
Main Authors: Luana Abballe, Angela Mastronuzzi, Evelina Miele, Andrea Carai, Zein Mersini Besharat, Marta Moretti, Enrico De Smaele, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti, Agnese Po
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pediatrics
Subjects:
medulloblastoma
numb
NUMB isoforms
cancer stem cells
neural stem cells
sonic hedgehog signaling
Online Access:https://www.frontiersin.org/article/10.3389/fped.2018.00315/full

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