Two-photon activated precision molecular photosensitizer targeting mitochondria

Molecules that target mitochondria have promising applications as anticancer agents. Here quinolizinium and benzimidazolium cations are shown to deactivate mitochondria through two-photon absorption in the near infrared range.

Bibliographic Details
Main Authors:	Inês F. A. Mariz, Sandra N. Pinto, Ana M. Santiago, José M. G. Martinho, Javier Recio, Juan J. Vaquero, Ana M. Cuadro, Ermelinda Maçôas
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-10-01
Series:	Communications Chemistry
Online Access:	https://doi.org/10.1038/s42004-021-00581-4

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spelling	doaj-7b70e4564d994e5a8c9ce1f7b5291afd2021-10-10T11:05:35ZengNature Publishing GroupCommunications Chemistry2399-36692021-10-014111110.1038/s42004-021-00581-4Two-photon activated precision molecular photosensitizer targeting mitochondriaInês F. A. Mariz0Sandra N. Pinto1Ana M. Santiago2José M. G. Martinho3Javier Recio4Juan J. Vaquero5Ana M. Cuadro6Ermelinda Maçôas7Centro de Química Estrutural (CQE) and Institute of Molecular Sciences (IMS), Instituto Superior Técnico, Universidade de LisboaInstitute for Bioengineering and Biosciences (IBB) Instituto Superior Técnico, Universidade de LisboaCentro de Química Estrutural (CQE) and Institute of Molecular Sciences (IMS), Instituto Superior Técnico, Universidade de LisboaCentro de Química Estrutural (CQE) and Institute of Molecular Sciences (IMS), Instituto Superior Técnico, Universidade de LisboaDepartamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, (IRYCIS)Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, (IRYCIS)Departamento de Química Orgánica y Química Inorgánica, Universidad de Alcalá, (IRYCIS)Centro de Química Estrutural (CQE) and Institute of Molecular Sciences (IMS), Instituto Superior Técnico, Universidade de LisboaMolecules that target mitochondria have promising applications as anticancer agents. Here quinolizinium and benzimidazolium cations are shown to deactivate mitochondria through two-photon absorption in the near infrared range.https://doi.org/10.1038/s42004-021-00581-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Inês F. A. Mariz Sandra N. Pinto Ana M. Santiago José M. G. Martinho Javier Recio Juan J. Vaquero Ana M. Cuadro Ermelinda Maçôas
spellingShingle	Inês F. A. Mariz Sandra N. Pinto Ana M. Santiago José M. G. Martinho Javier Recio Juan J. Vaquero Ana M. Cuadro Ermelinda Maçôas Two-photon activated precision molecular photosensitizer targeting mitochondria Communications Chemistry
author_facet	Inês F. A. Mariz Sandra N. Pinto Ana M. Santiago José M. G. Martinho Javier Recio Juan J. Vaquero Ana M. Cuadro Ermelinda Maçôas
author_sort	Inês F. A. Mariz
title	Two-photon activated precision molecular photosensitizer targeting mitochondria
title_short	Two-photon activated precision molecular photosensitizer targeting mitochondria
title_full	Two-photon activated precision molecular photosensitizer targeting mitochondria
title_fullStr	Two-photon activated precision molecular photosensitizer targeting mitochondria
title_full_unstemmed	Two-photon activated precision molecular photosensitizer targeting mitochondria
title_sort	two-photon activated precision molecular photosensitizer targeting mitochondria
publisher	Nature Publishing Group
series	Communications Chemistry
issn	2399-3669
publishDate	2021-10-01
description	Molecules that target mitochondria have promising applications as anticancer agents. Here quinolizinium and benzimidazolium cations are shown to deactivate mitochondria through two-photon absorption in the near infrared range.
url	https://doi.org/10.1038/s42004-021-00581-4
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Two-photon activated precision molecular photosensitizer targeting mitochondria

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