Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up

Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up

BACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients recei...

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Main Authors: DA Malatjalian, JB Ross, CN Williams, SJ Colwell, BJ Eastwood
Format: Article
Language:English
Published: Hindawi Limited 1996-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1996/213596
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spelling doaj-7b6ada2f977a452b81cdd61c007f23f82020-11-24T22:55:10ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001996-01-0110636937510.1155/1996/213596Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-UpDA Malatjalian0JB Ross1CN Williams2SJ Colwell3BJ Eastwood4Divisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaDivisions of Anatomical Pathology, Dermatology, Gastroenterology, Department of Community Health and Epidemiology, Dalhousie University and Victoria General Hospital, Halifax, Nova Scotia, CanadaBACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients received MTX over one to 11 years (mean 3.38), with baseline and annual follow-up liver biopsies. Clinical data were obtained by chart review. Statistical analysis evaluated the risks associated with obesity, diabetes, alcohol consumption and duration of therapy, with the histological grade of liver biopsies.http://dx.doi.org/10.1155/1996/213596
collection DOAJ
language English
format Article
sources DOAJ
author DA Malatjalian
JB Ross
CN Williams
SJ Colwell
BJ Eastwood
spellingShingle DA Malatjalian
JB Ross
CN Williams
SJ Colwell
BJ Eastwood
Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
Canadian Journal of Gastroenterology
author_facet DA Malatjalian
JB Ross
CN Williams
SJ Colwell
BJ Eastwood
author_sort DA Malatjalian
title Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
title_short Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
title_full Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
title_fullStr Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
title_full_unstemmed Methotrexate Hepatotoxicity in Psoriatics: Report of 104 Patients from Nova Scotia, with Analysis of Risks from Obesity, Diabetes and Alcohol Consumption During Long Term Follow-Up
title_sort methotrexate hepatotoxicity in psoriatics: report of 104 patients from nova scotia, with analysis of risks from obesity, diabetes and alcohol consumption during long term follow-up
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 1996-01-01
description BACKGROUND AND DESIGN: Methotrexate (MTX) hepatotoxicity in psoriatic patients is well recognized, but there are discrepancies in the reported incidence and associated risk factors. This retrospective study describes 104 Nova Scotian patients with psoriasis seen between 1979 and 1990. Patients received MTX over one to 11 years (mean 3.38), with baseline and annual follow-up liver biopsies. Clinical data were obtained by chart review. Statistical analysis evaluated the risks associated with obesity, diabetes, alcohol consumption and duration of therapy, with the histological grade of liver biopsies.
url http://dx.doi.org/10.1155/1996/213596
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