An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1–MECOM fusion transcripts

An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1–MECOM fusion transcripts

We report the first case of acute myeloid leukemia (AML) with RUNX1–MECOM fusion transcripts, showing marked eosinophilia. A 63-year old man admitted in August 2013, had previously been observed in April 2013, because of persisting homogeneous splenomegaly and increased LDH, which were initially att...

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Bibliographic Details
Main Authors: Fabio Forghieri, Sara Bigliardi, Monica Morselli, Leonardo Potenza, Valeria Fantuzzi, Laura Faglioni, Vincenzo Nasillo, Andrea Messerotti, Ambra Paolini, Mario Luppi
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Leukemia Research Reports
Subjects:
Acute myeloid leukemia
t(3;21)(q26;q22)
RUNX1–MECOM
Eosinophilia
Splenomegaly
Myeloproliferative neoplasm
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048914000211

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