The role of pramipexole in a severe Parkinson’s disease model in mice

The role of pramipexole in a severe Parkinson’s disease model in mice

Background: Pramipexole is one of a new generation of dopamine agonists. Recently there have been questions regarding its neuroprotective effects. These effects have been tested against various insults, which have yielded conflicting results. Methods: In this study, we introduced a combination of 1-...

Full description

Bibliographic Details
Main Authors: Seham Gad ElHak, Abdel Aziz Ghanem, Hasan Abdelghaffar, Sahar ElDakroury, Dina ElTantawy, Sara ElDosouky, Mohamed Salama
Format: Article
Language:English
Published: SAGE Publishing 2010-11-01
Series:Therapeutic Advances in Neurological Disorders
Online Access:https://doi.org/10.1177/1756285610389655
id doaj-7b5bf3fbdabf4014ba09ae171c452209
record_format Article
spelling doaj-7b5bf3fbdabf4014ba09ae171c4522092020-11-25T03:34:38ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28562010-11-01310.1177/1756285610389655The role of pramipexole in a severe Parkinson’s disease model in miceSeham Gad ElHakAbdel Aziz GhanemHasan AbdelghaffarSahar ElDakrouryDina ElTantawySara ElDosoukyMohamed SalamaBackground: Pramipexole is one of a new generation of dopamine agonists. Recently there have been questions regarding its neuroprotective effects. These effects have been tested against various insults, which have yielded conflicting results. Methods: In this study, we introduced a combination of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/paraquat to induce a severe Parkinson’s disease model. The mice, after receiving the combination of toxins, were evaluated using mortality rates and immunohistochemistry for degenerating tyrosine hydroxylase-positive neurons. Results and conclusions: Pramipexole was tested for its capacity to offer protection against neurotoxic the effects of MPTP/paraquat in this model; however, the results showed no improvement with pramipexole therapy.https://doi.org/10.1177/1756285610389655
collection DOAJ
language English
format Article
sources DOAJ
author Seham Gad ElHak
Abdel Aziz Ghanem
Hasan Abdelghaffar
Sahar ElDakroury
Dina ElTantawy
Sara ElDosouky
Mohamed Salama
spellingShingle Seham Gad ElHak
Abdel Aziz Ghanem
Hasan Abdelghaffar
Sahar ElDakroury
Dina ElTantawy
Sara ElDosouky
Mohamed Salama
The role of pramipexole in a severe Parkinson’s disease model in mice
Therapeutic Advances in Neurological Disorders
author_facet Seham Gad ElHak
Abdel Aziz Ghanem
Hasan Abdelghaffar
Sahar ElDakroury
Dina ElTantawy
Sara ElDosouky
Mohamed Salama
author_sort Seham Gad ElHak
title The role of pramipexole in a severe Parkinson’s disease model in mice
title_short The role of pramipexole in a severe Parkinson’s disease model in mice
title_full The role of pramipexole in a severe Parkinson’s disease model in mice
title_fullStr The role of pramipexole in a severe Parkinson’s disease model in mice
title_full_unstemmed The role of pramipexole in a severe Parkinson’s disease model in mice
title_sort role of pramipexole in a severe parkinson’s disease model in mice
publisher SAGE Publishing
series Therapeutic Advances in Neurological Disorders
issn 1756-2856
publishDate 2010-11-01
description Background: Pramipexole is one of a new generation of dopamine agonists. Recently there have been questions regarding its neuroprotective effects. These effects have been tested against various insults, which have yielded conflicting results. Methods: In this study, we introduced a combination of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)/paraquat to induce a severe Parkinson’s disease model. The mice, after receiving the combination of toxins, were evaluated using mortality rates and immunohistochemistry for degenerating tyrosine hydroxylase-positive neurons. Results and conclusions: Pramipexole was tested for its capacity to offer protection against neurotoxic the effects of MPTP/paraquat in this model; however, the results showed no improvement with pramipexole therapy.
url https://doi.org/10.1177/1756285610389655
work_keys_str_mv AT sehamgadelhak theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT abdelazizghanem theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT hasanabdelghaffar theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT sahareldakroury theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT dinaeltantawy theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT saraeldosouky theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT mohamedsalama theroleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT sehamgadelhak roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT abdelazizghanem roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT hasanabdelghaffar roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT sahareldakroury roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT dinaeltantawy roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT saraeldosouky roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
AT mohamedsalama roleofpramipexoleinasevereparkinsonsdiseasemodelinmice
_version_ 1724558524456894464

Similar Items