The Antifungal Plant Defensin HsAFP1 Is a Phosphatidic Acid-Interacting Peptide Inducing Membrane Permeabilization

The Antifungal Plant Defensin HsAFP1 Is a Phosphatidic Acid-Interacting Peptide Inducing Membrane Permeabilization

HsAFP1, a plant defensin isolated from coral bells (Heuchera sanguinea), is characterized by broad-spectrum antifungal activity. Previous studies indicated that HsAFP1 binds to specific fungal membrane components, which had hitherto not been identified, and induces mitochondrial dysfunction and cell...

Full description

Bibliographic Details
Main Authors: Tanne L. Cools, Kim Vriens, Caroline Struyfs, Sara Verbandt, Marcelo H. S. Ramada, Guilherme D. Brand, Carlos Bloch, Barbara Koch, Ana Traven, Jan W. Drijfhout, Liesbeth Demuyser, Soňa Kucharíková, Patrick Van Dijck, Dragana Spasic, Jeroen Lammertyn, Bruno P. A. Cammue, Karin Thevissen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Microbiology
Subjects:
plant defensins
yeast
antifungal mode of action
lipid membrane target
peptide internalization
membrane permeabilization
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.02295/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.02295/full

Similar Items