Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective

Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective

Past failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potent...

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Main Authors: Xing Huang, Gang Zhang, Xueli Bai, Tingbo Liang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
met
targeted therapy
drug resistance
autophagy
mtor
tumor immunity
cancer vaccine
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1818438
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spelling doaj-7b487265040948d4b8f11e5718d9e9b92021-09-24T14:41:25ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2020.18184381818438Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspectiveXing Huang0Gang Zhang1Xueli Bai2Tingbo Liang3Zhejiang UniversityZhejiang UniversityZhejiang UniversityZhejiang UniversityPast failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potential target for cancer vaccines. This paper briefly highlights novel research advances in this rapidly-evolving field in the perspective of autophagy, and discusses future directions for further investigation of MET-based cancer therapy and vaccination.http://dx.doi.org/10.1080/2162402X.2020.1818438mettargeted therapydrug resistanceautophagymtortumor immunitycancer vaccine
collection DOAJ
language English
format Article
sources DOAJ
author Xing Huang
Gang Zhang
Xueli Bai
Tingbo Liang
spellingShingle Xing Huang
Gang Zhang
Xueli Bai
Tingbo Liang
Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
OncoImmunology
met
targeted therapy
drug resistance
autophagy
mtor
tumor immunity
cancer vaccine
author_facet Xing Huang
Gang Zhang
Xueli Bai
Tingbo Liang
author_sort Xing Huang
title Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_short Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_full Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_fullStr Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_full_unstemmed Reviving the role of MET in liver cancer therapy and vaccination: an autophagic perspective
title_sort reviving the role of met in liver cancer therapy and vaccination: an autophagic perspective
publisher Taylor & Francis Group
series OncoImmunology
issn 2162-402X
publishDate 2020-01-01
description Past failures in clinical trials have dampened the enthusiasm for studying the HGF receptor MET and postponed the development of MET-targeted drugs for cancer therapy. However, new evidence suggests that, at least in liver cancer, MET is still a promising therapeutic target, and may also be a potential target for cancer vaccines. This paper briefly highlights novel research advances in this rapidly-evolving field in the perspective of autophagy, and discusses future directions for further investigation of MET-based cancer therapy and vaccination.
topic met
targeted therapy
drug resistance
autophagy
mtor
tumor immunity
cancer vaccine
url http://dx.doi.org/10.1080/2162402X.2020.1818438
work_keys_str_mv AT xinghuang revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
AT gangzhang revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
AT xuelibai revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
AT tingboliang revivingtheroleofmetinlivercancertherapyandvaccinationanautophagicperspective
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