Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

Evidence suggests that distinct splenic dendritic cell (DC) subsets activate either CD4+ or CD8+ T cells in vivo. This bias has been partially ascribed to differential antigen presentation; however, all DC subsets can activate both T cell lineages in vitro. Therefore, we tested whether the organizat...

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Bibliographic Details
Main Authors: Samuele Calabro, Dong Liu, Antonia Gallman, Manuela Sales L. Nascimento, Zizi Yu, Ting-ting Zhang, Pei Chen, Biyan Zhang, Lan Xu, Uthaman Gowthaman, Jayendra Kumar Krishnaswamy, Ann M. Haberman, Adam Williams, Stephanie C. Eisenbarth
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Subjects:
dendritic cell
spleen
T cell
red blood cell alloimmunization
CCR7
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310221

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