Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis

Objectives. To explore the relationship between insulin levels and nonpsychotic dementia. Methods. Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychot...

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Main Authors: Qiu-xia Pan, Xiao-juan Li, Yue-yun Liu, Fang-fang Wang, Ya-jing Hou, Qing-lai Bian, Wen-qi Qiu, Zhi-yi Yan, You-ming Jiang, Jia-xu Chen
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2017/1230713
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spelling doaj-7b453cf1722d4330a4fed41ed2a616dc2020-11-24T20:58:01ZengHindawi LimitedNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/12307131230713Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-AnalysisQiu-xia Pan0Xiao-juan Li1Yue-yun Liu2Fang-fang Wang3Ya-jing Hou4Qing-lai Bian5Wen-qi Qiu6Zhi-yi Yan7You-ming Jiang8Jia-xu Chen9School of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaSchool of Basic Medical Science, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Chaoyang, Beijing 100029, ChinaObjectives. To explore the relationship between insulin levels and nonpsychotic dementia. Methods. Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychotic dementia or abnormal insulin levels in which insulin levels or MMSE scores (events in nonpsychotic dementia) were the outcome measures. Random-effects models were chosen for this meta-analysis. Sample size, mean, s.d., and events were primarily used to generate effect sizes (with the PRIMA registration number CRD42017069860). Results. 50 articles met the final inclusion criteria. Insulin levels in cerebrospinal fluid were lower (Hedges’ g = 1.196, 95% CI = 0.238 to 2.514, and P=0.014), while the levels in peripheral blood were higher in nonpsychotic dementia patients (Hedges’ g = 0.853 and 95% CI = 0.579 to 1.127), and MMSE scores were significantly lower in the high insulin group than in the healthy control group (Hedges’ g = 0.334, 95% CI = 0.249 to 0.419, and P=0.000). Conclusions. Our comprehensive results indicate that blood insulin levels may increase in patients with nonpsychotic dementia.http://dx.doi.org/10.1155/2017/1230713
collection DOAJ
language English
format Article
sources DOAJ
author Qiu-xia Pan
Xiao-juan Li
Yue-yun Liu
Fang-fang Wang
Ya-jing Hou
Qing-lai Bian
Wen-qi Qiu
Zhi-yi Yan
You-ming Jiang
Jia-xu Chen
spellingShingle Qiu-xia Pan
Xiao-juan Li
Yue-yun Liu
Fang-fang Wang
Ya-jing Hou
Qing-lai Bian
Wen-qi Qiu
Zhi-yi Yan
You-ming Jiang
Jia-xu Chen
Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
Neural Plasticity
author_facet Qiu-xia Pan
Xiao-juan Li
Yue-yun Liu
Fang-fang Wang
Ya-jing Hou
Qing-lai Bian
Wen-qi Qiu
Zhi-yi Yan
You-ming Jiang
Jia-xu Chen
author_sort Qiu-xia Pan
title Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
title_short Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
title_full Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
title_fullStr Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
title_full_unstemmed Relationship between Insulin Levels and Nonpsychotic Dementia: A Systematic Review and Meta-Analysis
title_sort relationship between insulin levels and nonpsychotic dementia: a systematic review and meta-analysis
publisher Hindawi Limited
series Neural Plasticity
issn 2090-5904
1687-5443
publishDate 2017-01-01
description Objectives. To explore the relationship between insulin levels and nonpsychotic dementia. Methods. Six electronic databases (PubMed, Cochrane, SCI, CNKI, VIP, and Wanfang) were searched from January 1, 2007, to March 1, 2017. Experimental or observational studies that enrolled people with nonpsychotic dementia or abnormal insulin levels in which insulin levels or MMSE scores (events in nonpsychotic dementia) were the outcome measures. Random-effects models were chosen for this meta-analysis. Sample size, mean, s.d., and events were primarily used to generate effect sizes (with the PRIMA registration number CRD42017069860). Results. 50 articles met the final inclusion criteria. Insulin levels in cerebrospinal fluid were lower (Hedges’ g = 1.196, 95% CI = 0.238 to 2.514, and P=0.014), while the levels in peripheral blood were higher in nonpsychotic dementia patients (Hedges’ g = 0.853 and 95% CI = 0.579 to 1.127), and MMSE scores were significantly lower in the high insulin group than in the healthy control group (Hedges’ g = 0.334, 95% CI = 0.249 to 0.419, and P=0.000). Conclusions. Our comprehensive results indicate that blood insulin levels may increase in patients with nonpsychotic dementia.
url http://dx.doi.org/10.1155/2017/1230713
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