Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

Upregulation of METTL14 mediates the elevation of PERP mRNA N6 adenosine methylation promoting the growth and metastasis of pancreatic cancer

Abstract Background Pancreatic cancer is one of the most lethal human cancers. N 6-methyladenosine (m6A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role in pancreatic cancer remains elusive. Methods LC/MS was used to pr...

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Bibliographic Details
Main Authors: Min Wang, Jun Liu, Yan Zhao, Ruizhi He, Xiaodong Xu, Xingjun Guo, Xu Li, Simiao Xu, Ji Miao, Jianpin Guo, Hang Zhang, Jun Gong, Feng Zhu, Rui Tian, Chengjian Shi, Feng Peng, Yechen Feng, Shuo Yu, Yu Xie, Jianxin Jiang, Min Li, Wenyi Wei, Chuan He, Renyi Qin
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Molecular Cancer
Subjects:
Pancreatic cancer
N 6-methyladenosine
m6A
METTL14
PERP
Online Access:http://link.springer.com/article/10.1186/s12943-020-01249-8

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