Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.

Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration--defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsin tr...

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Bibliographic Details
Main Authors: Manish Jaiswal, Nele A Haelterman, Hector Sandoval, Bo Xiong, Taraka Donti, Auinash Kalsotra, Shinya Yamamoto, Thomas A Cooper, Brett H Graham, Hugo J Bellen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002197