General characteristics of the melanogenesis process with particular emphasis on the role of the PAX3 gene
Melanogenesis is a dynamic process of biological transformations leading to the formation of copolymeric dyes - melanins, which act as a protector against the ultraviolet radiation (UV) and reactive oxygen species (ROS). The process of these compounds formation is carried out by an enzymati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Genetics Society
2018-01-01
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| Series: | Genetika |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0534-0012/2018/0534-00121803111B.pdf |
| Summary: | Melanogenesis is a dynamic process of biological transformations leading to
the formation of copolymeric dyes - melanins, which act as a protector
against the ultraviolet radiation (UV) and reactive oxygen species (ROS).
The process of these compounds formation is carried out by an enzymatic
apparatus in specialized melanocyte organelles - melanosomes. Particularly
from the point of view of biochemistry, melanins synthesis occurring depend
to a large extent not only on genetic but also on environmental conditions.
Pax3 is an important candidate in research on genetic conditioning of animal
colors pattern due to the fact that his gene expression product is a highly
conserved transcription factor that during embryonic development is one of
the elements responsible for regulating stem cell differentiation of the
neural crest into melanocytes. Moreover during individual life Pax3 is
involved in the response of melanocytic units to UV radiation.
Mutations/polymorphisms of the Pax3 gene are the cause of the occurrence of
some color varieties, as well as developmental disorders. |
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| ISSN: | 0534-0012 1820-6069 |