Histological changes of kidney in diabetic nephropathy
Diabetes mellitus is the most common cause of chronic renal disorders and end-stage kidney disease in developed countries. It is the major cause of dialysis and transplantation. Failure in renal function causes wide disorders in the body. Diabetes results in wide range of alterations in the renal ti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2015-07-01
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| Series: | Caspian Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://caspjim.com/browse.php?a_code=A-10-348-1&slc_lang=en&sid=1 |
| Summary: | Diabetes mellitus is the most common cause of chronic
renal disorders and end-stage kidney disease in developed countries. It is the
major cause of dialysis and transplantation. Failure in renal function causes
wide disorders in the body. Diabetes results in wide range of alterations in
the renal tissue. It is believed that early
histological changes in diabetic nephropathy are detectable 2 years after
diabetes is diagnosed. The glumerular alterations are the most important lesions in the diabetic nephropathy (DN). The Renal Pathology Society provides
a new pathological classification for the detection of histopathology of DN. It divides diabetic
nephropathy into four hierarchical glomerular lesions. Alloxan
or streptozotocin induced diabetic rat is the one most widely used specie to
study DN. Histological changes in the rat DN closely resemble the human disease
and the most information of this review was obtained through the study of rat
DN. All cell types of the kidney such as
mesangial cells, podocytes and tubulointerstitial cells are liable to be
affected in the event of DN. Severity of renal lesions is associated to the
clinical aspect of renal outcome, but the aim of this article was only to
review the histological changes of kidney in diabetes mellitus. |
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| ISSN: | 2008-6164 2008-6172 |