Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics

Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics

Down syndrome is a complex disease that has challenged molecular and cellular research for more than 50 years. Understanding the molecular bases of morphological, cellular, and functional alterations resulting from the presence of an additional complete chromosome 21 would aid in targeting specific...

Full description

Bibliographic Details
Main Author: Nicole Créau
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2012/171639
id doaj-7b37d533370f40f594e20b1193be5c8a
record_format Article
spelling doaj-7b37d533370f40f594e20b1193be5c8a2020-11-24T22:07:40ZengHindawi LimitedNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/171639171639Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for TherapeuticsNicole Créau0Unité de Biologie Fonctionnelle et Adaptative (BFA), Sorbonne Paris Cité, Universite Paris Diderot, EAC4413 CNRS, 75205 Paris Cedex 13, FranceDown syndrome is a complex disease that has challenged molecular and cellular research for more than 50 years. Understanding the molecular bases of morphological, cellular, and functional alterations resulting from the presence of an additional complete chromosome 21 would aid in targeting specific genes and pathways for rescuing some phenotypes. Recently, progress has been made by characterization of brain alterations in mouse models of Down syndrome. This review will highlight the main molecular and cellular findings recently described for these models, particularly with respect to their relationship to Down syndrome phenotypes.http://dx.doi.org/10.1155/2012/171639
collection DOAJ
language English
format Article
sources DOAJ
author Nicole Créau
spellingShingle Nicole Créau
Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
Neural Plasticity
author_facet Nicole Créau
author_sort Nicole Créau
title Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
title_short Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
title_full Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
title_fullStr Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
title_full_unstemmed Molecular and Cellular Alterations in Down Syndrome: Toward the Identification of Targets for Therapeutics
title_sort molecular and cellular alterations in down syndrome: toward the identification of targets for therapeutics
publisher Hindawi Limited
series Neural Plasticity
issn 2090-5904
1687-5443
publishDate 2012-01-01
description Down syndrome is a complex disease that has challenged molecular and cellular research for more than 50 years. Understanding the molecular bases of morphological, cellular, and functional alterations resulting from the presence of an additional complete chromosome 21 would aid in targeting specific genes and pathways for rescuing some phenotypes. Recently, progress has been made by characterization of brain alterations in mouse models of Down syndrome. This review will highlight the main molecular and cellular findings recently described for these models, particularly with respect to their relationship to Down syndrome phenotypes.
url http://dx.doi.org/10.1155/2012/171639
work_keys_str_mv AT nicolecreau molecularandcellularalterationsindownsyndrometowardtheidentificationoftargetsfortherapeutics
_version_ 1725819209935486976

Similar Items