Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells

Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells

Influence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4...

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Main Authors: L. S. Starykovych, M. O. Starykovych, A. N. Rechytskyi, V. A. Yeresko, T. U. Kosyak, N. O. Sybirna
Format: Article
Language:English
Published: Львівський національний університет імені Івана Франка 2009-09-01
Series:Біологічні студії
Subjects:
spirocarbone
pyrrolopyrimidine
cytotoxic activity
apoptosis
leukemia cells
l1210
cem-t4 lines
Online Access:http://publications.lnu.edu.ua/journals/index.php/biology/article/view/473
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spelling doaj-7b374c8e46ba46b0b3e5a0d258999ca92021-08-02T21:25:54ZengЛьвівський національний університет імені Івана ФранкаБіологічні студії1996-45362311-07832009-09-0132939810.30970/sbi.0302.028Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cellsL. S. Starykovych0M. O. Starykovych1https://orcid.org/0000-0003-0200-7639A. N. Rechytskyi2V. A. Yeresko3T. U. Kosyak4N. O. Sybirna5https://orcid.org/0000-0002-9217-3931Ivan Franko National University of Lviv, UkraineInstitute of Cell Biology, NAS of UkraineState University of Kherson, UkraineState University of Kherson, UkraineState University of Kherson, UkraineIvan Franko National University of Lviv, UkraineInfluence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4 lines of mouse and human, res­pectively was studied. Cytotoxic effect of spirocarbone towards L1210 cells accompa­nied by apoptotic fragmen­tation of nuclear DNA.http://publications.lnu.edu.ua/journals/index.php/biology/article/view/473spirocarbonepyrrolopyrimidinecytotoxic activityapoptosisleukemia cellsl1210cem-t4 lines
collection DOAJ
language English
format Article
sources DOAJ
author L. S. Starykovych
M. O. Starykovych
A. N. Rechytskyi
V. A. Yeresko
T. U. Kosyak
N. O. Sybirna
spellingShingle L. S. Starykovych
M. O. Starykovych
A. N. Rechytskyi
V. A. Yeresko
T. U. Kosyak
N. O. Sybirna
Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
Біологічні студії
spirocarbone
pyrrolopyrimidine
cytotoxic activity
apoptosis
leukemia cells
l1210
cem-t4 lines
author_facet L. S. Starykovych
M. O. Starykovych
A. N. Rechytskyi
V. A. Yeresko
T. U. Kosyak
N. O. Sybirna
author_sort L. S. Starykovych
title Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
title_short Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
title_full Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
title_fullStr Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
title_full_unstemmed Influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
title_sort influence of spirocarbone and derivates of pyrrolo pyrimidinediones of survival of leukemia cells
publisher Львівський національний університет імені Івана Франка
series Біологічні студії
issn 1996-4536
2311-0783
publishDate 2009-09-01
description Influence of spirocarbone and derivates of pyrrolopyrimidinediones (1,6-dimethyl-4-phenyl-1,2,3,4,5,7-hexahydropyrolo-[3,4-d]-pyrimidindione-2,5(1Н), and 1,6-dimethyl-4-(2-threefluoromethylphenyl)-1,2,3,4,5,7-hexahydropyrrolo-[3,4-d]-pyrimidinedione-2,5(1Н) on the leukemia cells of L1210 and CEM-T4 lines of mouse and human, res­pectively was studied. Cytotoxic effect of spirocarbone towards L1210 cells accompa­nied by apoptotic fragmen­tation of nuclear DNA.
topic spirocarbone
pyrrolopyrimidine
cytotoxic activity
apoptosis
leukemia cells
l1210
cem-t4 lines
url http://publications.lnu.edu.ua/journals/index.php/biology/article/view/473
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