Polymyxins as novel and safe mucosal adjuvants to induce humoral immune responses in mice.

Polymyxins as novel and safe mucosal adjuvants to induce humoral immune responses in mice.

There is currently an urgent need to develop safe and effective adjuvants for enhancing vaccine-induced antigen-specific immune responses. We demonstrate here that intranasal immunization with clinically used polypeptide antibiotics, polymyxin B (PMB) and colistin (CL), along with ovalbumin (OVA), i...

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Bibliographic Details
Main Authors: Naoto Yoshino, Masahiro Endo, Hiroyuki Kanno, Naomi Matsukawa, Reiko Tsutsumi, Ryosuke Takeshita, Shigehiro Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3623863?pdf=render

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