EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP

EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP

Effectiveness of a supramolecular nanotech-based Albendazole – Fenbendazole complex has been tested using the Drug Delivery System. Tests for efficacy of new drugs Albendazole and Fenbendazole were conducted on 37 sheep spontaneously infected with Nematodirus sp. and other gastrointestinal strongyla...

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Main Authors: A. I. Varlamova, V. A. Dolgoshev, K. M. Sadov, E. E. Belova, I. I. Glamazdin, S. S. Halikov, Yu. S. Chistyachenko, A. V. Dushkin, S. D. Durdusov, I. A. Arkhipov
Format: Article
Language:Russian
Published: Federal Scientific Centre VIEV 2016-05-01
Series:Российский паразитологический журнал
Subjects:
sheep
gastrointestinal strongylatosis
supramolecular complex
albendazole
fenbendazole
arabinogalactan
effectiveness
Online Access:https://vniigis.elpub.ru/jour/article/view/137
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spelling doaj-7b2b299d3b3748839c1c823536a1d3d22021-09-16T19:27:08ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432016-05-01017174137EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEPA. I. Varlamova0V. A. Dolgoshev1K. M. Sadov2E. E. Belova3I. I. Glamazdin4S. S. Halikov5Yu. S. Chistyachenko6A. V. Dushkin7S. D. Durdusov8I. A. Arkhipov9All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants 117218, Moscow, B. Cheremushkinskaya str., 28Samara Research Veterinary StationSamara Research Veterinary StationAll-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants 117218, Moscow, B. Cheremushkinskaya str., 28All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants 117218, Moscow, B. Cheremushkinskaya str., 28A. N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS) 119991, Moscow, Vavilov str., 28Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of RAS 630128, Novosibirsk, 18, Kutateladze str.Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of RAS 630128, Novosibirsk, 18, Kutateladze str.Moscow Academy of Economics and Law, Kalmyk Branch Elista, 5 Gorodovokov str.All-Russian Scientific Research Institute of fundamental and applied parasitology of animals and plants 117218, Moscow, B. Cheremushkinskaya str., 28Effectiveness of a supramolecular nanotech-based Albendazole – Fenbendazole complex has been tested using the Drug Delivery System. Tests for efficacy of new drugs Albendazole and Fenbendazole were conducted on 37 sheep spontaneously infected with Nematodirus sp. and other gastrointestinal strongylates in agricultural farm «Leninsky Put’» located in Pestravsky district of Samara region. The supra-molecular Albendazole – Arabinogalactan complex at a dose of 1,0 mg/kg of active ingredient and the base Albendazole at a dose of 10 mg/kg have shown a 100 % effectiveness. Albendazole – Chitosan complex has shown a 87,5 % extenseffectiveness and a 98,4 % reduction in number of nematode eggs in feces. The effectiveness of supramolecular Fenbendazole – polymer complex was lower.https://vniigis.elpub.ru/jour/article/view/137sheepgastrointestinal strongylatosissupramolecular complexalbendazolefenbendazolearabinogalactaneffectiveness
collection DOAJ
language Russian
format Article
sources DOAJ
author A. I. Varlamova
V. A. Dolgoshev
K. M. Sadov
E. E. Belova
I. I. Glamazdin
S. S. Halikov
Yu. S. Chistyachenko
A. V. Dushkin
S. D. Durdusov
I. A. Arkhipov
spellingShingle A. I. Varlamova
V. A. Dolgoshev
K. M. Sadov
E. E. Belova
I. I. Glamazdin
S. S. Halikov
Yu. S. Chistyachenko
A. V. Dushkin
S. D. Durdusov
I. A. Arkhipov
EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
Российский паразитологический журнал
sheep
gastrointestinal strongylatosis
supramolecular complex
albendazole
fenbendazole
arabinogalactan
effectiveness
author_facet A. I. Varlamova
V. A. Dolgoshev
K. M. Sadov
E. E. Belova
I. I. Glamazdin
S. S. Halikov
Yu. S. Chistyachenko
A. V. Dushkin
S. D. Durdusov
I. A. Arkhipov
author_sort A. I. Varlamova
title EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
title_short EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
title_full EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
title_fullStr EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
title_full_unstemmed EFFECTIVENESS OF SUPRAMOLECULAR ANTHELMINTIC COMPLEXES APPLIED UNDER WORKING CONDITIONS FOR TREATMENT OF GASTROINTESTINAL STRONGYLATOSIS IN SHEEP
title_sort effectiveness of supramolecular anthelmintic complexes applied under working conditions for treatment of gastrointestinal strongylatosis in sheep
publisher Federal Scientific Centre VIEV
series Российский паразитологический журнал
issn 1998-8435
2541-7843
publishDate 2016-05-01
description Effectiveness of a supramolecular nanotech-based Albendazole – Fenbendazole complex has been tested using the Drug Delivery System. Tests for efficacy of new drugs Albendazole and Fenbendazole were conducted on 37 sheep spontaneously infected with Nematodirus sp. and other gastrointestinal strongylates in agricultural farm «Leninsky Put’» located in Pestravsky district of Samara region. The supra-molecular Albendazole – Arabinogalactan complex at a dose of 1,0 mg/kg of active ingredient and the base Albendazole at a dose of 10 mg/kg have shown a 100 % effectiveness. Albendazole – Chitosan complex has shown a 87,5 % extenseffectiveness and a 98,4 % reduction in number of nematode eggs in feces. The effectiveness of supramolecular Fenbendazole – polymer complex was lower.
topic sheep
gastrointestinal strongylatosis
supramolecular complex
albendazole
fenbendazole
arabinogalactan
effectiveness
url https://vniigis.elpub.ru/jour/article/view/137
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