Effect of MgCl<sub>2</sub> and GdCl<sub>3</sub> on ORAI1 Expression and Store-Operated Ca<sup>2+</sup> Entry in Megakaryocytes

Effect of MgCl<sub>2</sub> and GdCl<sub>3</sub> on ORAI1 Expression and Store-Operated Ca<sup>2+</sup> Entry in Megakaryocytes

In chronic kidney disease, hyperphosphatemia upregulates the Ca<sup>2+</sup> channel ORAI and its activating Ca<sup>2+</sup> sensor STIM in megakaryocytes and platelets. ORAI1 and STIM1 accomplish store-operated Ca<sup>2+</sup> entry (SOCE) and play a key role in...

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Bibliographic Details
Main Authors: Kuo Zhou, Xuexue Zhu, Ke Ma, Jibin Liu, Bernd Nürnberg, Meinrad Gawaz, Florian Lang
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
SOCE
ORAI1,2,3
STIM1,2
SGK1
NFAT5
Mg<sup>2+</sup>
Online Access:https://www.mdpi.com/1422-0067/22/7/3292

Internet

https://www.mdpi.com/1422-0067/22/7/3292

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