Overexpression of ABCC2 and NF-Κβ/p65 with Reduction in Cisplatin and 4OH-Tamoxifen Sensitivity in MCF-7 Breast Cancer Cells: The Influence of TNF-α

Overexpression of ABCC2 and NF-Κβ/p65 with Reduction in Cisplatin and 4OH-Tamoxifen Sensitivity in MCF-7 Breast Cancer Cells: The Influence of TNF-α

Background: TNF-α, as a pro-inflammatory cytokine in the tumor microenvironment is able to regulate the expression and function of various ATP binding cassette (ABC) transporters involved in clinical drug resistance and among them, ABCC2 transporter is represented to contribute to cancer multidrug r...

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Bibliographic Details
Main Authors: Nafiseh Sadat Alamolhodaei, Hatam Rashidpour, Melika Ehtesham gharaee, Javad Behravan, Fatemeh Mosaffa
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-06-01
Series:Pharmaceutical Sciences
Subjects:
breast cancer
tnf-α
17β-estradiol
abcc2
nf-κb/p65
cisplatin
4oh-tamoxifen
Online Access:https://ps.tbzmed.ac.ir/PDF/ps-33200

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