PGC‐1α inhibits polyamine metabolism in Cyclin E1‐driven ovarian cancer

PGC‐1α inhibits polyamine metabolism in Cyclin E1‐driven ovarian cancer

Abstract Aim Cyclin E1‐driven ovarian cancer (OvCa) is characterized with metabolic shift. In this study, we aim to pinpoint the metabolic pathway altered and assess its therapeutic potential. Methods In silico reproduction of TCGA ovarian cancer dataset and functional annotation using GSEA was perf...

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Bibliographic Details
Main Authors: Ting Guo, Bin Li, Chao Gu, Xiuying Chen, Mengxin Han, Xiaocheng Liu, Congjian Xu
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Cancer Medicine
Subjects:
CCNE1
High‐grade serous ovarian cancer
polyamine metabolism
Online Access:https://doi.org/10.1002/cam4.2637

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