Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

Bibliographic Details
Main Authors:	Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Alzheimer’s Disease Neuroimaging Initiative, the Swedish BioFinder Study
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15701-2

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spelling	doaj-7af80602b80f442faa5519b7ab861cc22021-05-30T11:16:17ZengNature Publishing GroupNature Communications2041-17232020-05-0111111510.1038/s41467-020-15701-2Spread of pathological tau proteins through communicating neurons in human Alzheimer's diseaseJacob W. Vogel0Yasser Iturria-Medina1Olof T. Strandberg2Ruben Smith3Elizabeth Levitis4Alan C. Evans5Oskar Hansson6Alzheimer’s Disease Neuroimaging Initiativethe Swedish BioFinder StudyMontreal Neurological Institute, McGill UniversityMontreal Neurological Institute, McGill UniversityClinical Memory Research Unit, Lund UniversityClinical Memory Research Unit, Lund UniversityMontreal Neurological Institute, McGill UniversityMontreal Neurological Institute, McGill UniversityClinical Memory Research Unit, Lund UniversityThe tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloidhttps://doi.org/10.1038/s41467-020-15701-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jacob W. Vogel Yasser Iturria-Medina Olof T. Strandberg Ruben Smith Elizabeth Levitis Alan C. Evans Oskar Hansson Alzheimer’s Disease Neuroimaging Initiative the Swedish BioFinder Study
spellingShingle	Jacob W. Vogel Yasser Iturria-Medina Olof T. Strandberg Ruben Smith Elizabeth Levitis Alan C. Evans Oskar Hansson Alzheimer’s Disease Neuroimaging Initiative the Swedish BioFinder Study Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease Nature Communications
author_facet	Jacob W. Vogel Yasser Iturria-Medina Olof T. Strandberg Ruben Smith Elizabeth Levitis Alan C. Evans Oskar Hansson Alzheimer’s Disease Neuroimaging Initiative the Swedish BioFinder Study
author_sort	Jacob W. Vogel
title	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_short	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_full	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_fullStr	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_full_unstemmed	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_sort	spread of pathological tau proteins through communicating neurons in human alzheimer's disease
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid
url	https://doi.org/10.1038/s41467-020-15701-2
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Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

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