c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway

c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway

AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases (JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in the retinal ganglion cells (RGCs) by double-immunofluorescent staining. Then we...

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Bibliographic Details
Main Authors: Rong-Rong Wang, Cheng-Fang Li, De-Zu Wang, Cheng-Wu Zhang, Gui-Xiang Liu
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2019-01-01
Series:International Journal of Ophthalmology
Subjects:
retinal ganglion cells
c-jun n-terminal kinases
optic nerve
mitochondria
noxa
neurotrauma
Online Access:http://www.ijo.cn/en_publish/2019/1/20190105.pdf

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