Intraosseous malignant peripheral nerve sheath tumor of distal femur detected with fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography imaging

• Main Authors: Koramadai Karuppusamy Kamaleshwaran, Firoz Rajan, Vyshakh Mohanan, Ajit Sugunan Shinto
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2016-01-01
• Series: Journal of Mahatma Gandhi Institute of Medical Sciences
• Subjects: Distal femur; fluorine.18 fluorodeoxyglucose positron emission tomography/computed tomography; intraosseous; malignant peripheral nerve sheath tumor
• Online Access: http://www.jmgims.co.in/article.asp?issn=0971-9903;year=2016;volume=21;issue=2;spage=151;epage=153;aulast=Kamaleshwaran

Malignant peripheral nerve sheath tumor (MPNST) is a malignant soft tissue tumor arising from peripheral nerve sheath cells. MPNST is uncommon and can be associated with neurofibromatosis Type I (NF-I). MPNST involving bone is very rare, and we report the case of MPNST involving the distal femur in a patient without NF-I. A 17-year-old boy presented with a history of left knee joint pain and X-ray showed lytic lesion in the distal part of left femur. He was referred for fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to find out the extent of disease. PET/CT showed intense FDG uptake in the lobulated well-defined lesion in the medial part of left distal femur. He underwent biopsy from the lesion which confirmed MPNST.