A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases

A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases

Vemurafenib is approved by the FDA for the management of unresectable or metastatic melanoma. However, its role as a neoadjuvant therapy has not been determined. We present the first documented case in which vemurafenib induced complete tumor necrosis of both lymph node and brain metastases within o...

Full description

Bibliographic Details
Main Authors: Idit Melnik, Michal Lotem, Boris Yoffe
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Case Reports in Oncological Medicine
Online Access:http://dx.doi.org/10.1155/2013/794239
id doaj-7ad1d77a1fe143c4984269d7da0241e0
record_format Article
spelling doaj-7ad1d77a1fe143c4984269d7da0241e02020-11-24T21:04:02ZengHindawi LimitedCase Reports in Oncological Medicine2090-67062090-67142013-01-01201310.1155/2013/794239794239A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma MetastasesIdit Melnik0Michal Lotem1Boris Yoffe2Department of General and Vascular Surgery, Barzilai Medical Center, Hahistadrut Street 2, 78278 Ashkelon, IsraelCenter for Melanoma and Cancer Immunotherapy, Sharett Institute of Oncology, Hadassah Hebrew University Medical Center, P.O. Box 12000, 91120 Jerusalem, IsraelDepartment of General and Vascular Surgery, Barzilai Medical Center, Hahistadrut Street 2, 78278 Ashkelon, IsraelVemurafenib is approved by the FDA for the management of unresectable or metastatic melanoma. However, its role as a neoadjuvant therapy has not been determined. We present the first documented case in which vemurafenib induced complete tumor necrosis of both lymph node and brain metastases within one month or less, an outcome that indicated that the patient was a good candidate for excisional surgery.http://dx.doi.org/10.1155/2013/794239
collection DOAJ
language English
format Article
sources DOAJ
author Idit Melnik
Michal Lotem
Boris Yoffe
spellingShingle Idit Melnik
Michal Lotem
Boris Yoffe
A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
Case Reports in Oncological Medicine
author_facet Idit Melnik
Michal Lotem
Boris Yoffe
author_sort Idit Melnik
title A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_short A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_full A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_fullStr A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_full_unstemmed A New Role of Vemurafenib as a Neoadjuvant Treatment of Axillary and Brain Melanoma Metastases
title_sort new role of vemurafenib as a neoadjuvant treatment of axillary and brain melanoma metastases
publisher Hindawi Limited
series Case Reports in Oncological Medicine
issn 2090-6706
2090-6714
publishDate 2013-01-01
description Vemurafenib is approved by the FDA for the management of unresectable or metastatic melanoma. However, its role as a neoadjuvant therapy has not been determined. We present the first documented case in which vemurafenib induced complete tumor necrosis of both lymph node and brain metastases within one month or less, an outcome that indicated that the patient was a good candidate for excisional surgery.
url http://dx.doi.org/10.1155/2013/794239
work_keys_str_mv AT iditmelnik anewroleofvemurafenibasaneoadjuvanttreatmentofaxillaryandbrainmelanomametastases
AT michallotem anewroleofvemurafenibasaneoadjuvanttreatmentofaxillaryandbrainmelanomametastases
AT borisyoffe anewroleofvemurafenibasaneoadjuvanttreatmentofaxillaryandbrainmelanomametastases
AT iditmelnik newroleofvemurafenibasaneoadjuvanttreatmentofaxillaryandbrainmelanomametastases
AT michallotem newroleofvemurafenibasaneoadjuvanttreatmentofaxillaryandbrainmelanomametastases
AT borisyoffe newroleofvemurafenibasaneoadjuvanttreatmentofaxillaryandbrainmelanomametastases
_version_ 1716772202067525632

Similar Items