Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.
Bibliographic Details
| Main Authors: |
Saskia Heybrock,
Kristiina Kanerva,
Ying Meng,
Chris Ing,
Anna Liang,
Zi-Jian Xiong,
Xialian Weng,
Young Ah Kim,
Richard Collins,
William Trimble,
Régis Pomès,
Gilbert G. Privé,
Wim Annaert,
Michael Schwake,
Joerg Heeren,
Renate Lüllmann-Rauch,
Sergio Grinstein,
Elina Ikonen,
Paul Saftig,
Dante Neculai |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2019-08-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/s41467-019-11425-0
|
|---|
