Modulating the Mechanical Activation of TRPV4 at the Cell-Substrate Interface
Ion channels activated by mechanical inputs are important force sensing molecules in a wide array of mammalian cells and tissues. The transient receptor potential channel, TRPV4, is a polymodal, nonselective cation channel that can be activated by mechanical inputs but only if stimuli are applied di...
Main Authors: | Setareh Sianati, Lioba Schroeter, Jessica Richardson, Andy Tay, Shireen R. Lamandé, Kate Poole |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-01-01
|
Series: | Frontiers in Bioengineering and Biotechnology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2020.608951/full |
Similar Items
-
Analysis of Mechanically Activated Ion Channels at the Cell-Substrate Interface: Combining Pillar Arrays and Whole-Cell Patch-Clamp
by: Setareh Sianati, et al.
Published: (2019-03-01) -
The ion selectivity filter is not an activation gate in TRPV1-3 channels
by: Andrés Jara-Oseguera, et al.
Published: (2019-11-01) -
Expression of Transient Receptor Potential Vanilloid (TRPV) Channels in Different Passages of Articular Chondrocytes
by: Richard Barrett-Jolley, et al.
Published: (2012-04-01) -
An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel
by: Fan Yang, et al.
Published: (2020-10-01) -
OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
by: Swetha E Murthy, et al.
Published: (2018-11-01)