Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient

Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient

Abstract Background Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehen...

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Bibliographic Details
Main Authors: Hye Won Lee, Woosung Chung, Hae-Ock Lee, Da Eun Jeong, Areum Jo, Joung Eun Lim, Jeong Hee Hong, Do-Hyun Nam, Byong Chang Jeong, Se Hoon Park, Kyeung-Min Joo, Woong-Yang Park
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Medicine
Subjects:
Treatment resistance
Tumoral heterogeneity
Tumor microenvironment
Single-cell RNA sequencing
Muscle-invasive urothelial bladder cancer
Online Access:http://link.springer.com/article/10.1186/s13073-020-00741-6

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