L-Norvaline, a new therapeutic agent against Alzheimer’s disease

L-Norvaline, a new therapeutic agent against Alzheimer’s disease

Growing evidence highlights the role of arginase activity in the manifestation of Alzheimer’s disease (AD). Upregulation of arginase was shown to contribute to neurodegeneration. Regulation of arginase activity appears to be a promising approach for interfering with the pathogenesis of AD. Therefore...

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Bibliographic Details
Main Authors: Baruh Polis, Kolluru D Srikanth, Vyacheslav Gurevich, Hava Gil-Henn, Abraham O Samson
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
dementia; arginase inhibition; arginine; urea cycle; microgliosis; neuroinflammation; cytokines; tumor necrosis factor; mTOR; neurodegeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=9;spage=1562;epage=1572;aulast=Polis

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=9;spage=1562;epage=1572;aulast=Polis

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