The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer

The early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuou...

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Main Authors: Dhruvajyoti Roy, Andreas Pascher, Mazen A. Juratli, Judith C. Sporn
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/22/11/5601
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spelling doaj-7aaaab63f694464e85a2059bfae24ea72021-06-01T01:04:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225601560110.3390/ijms22115601The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of CancerDhruvajyoti Roy0Andreas Pascher1Mazen A. Juratli2Judith C. Sporn3Helio Health, Irvine, CA 92618, USADepartment of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, GermanyDepartment of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, GermanyDepartment of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, GermanyThe early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuously monitor disease progression and treatment efficacy. Various methods have been implemented to isolate and purify bio-analytes in liquid biopsy specimens. Aptamers are short oligonucleotides consisting of either DNA or RNA that are capable of binding to target molecules with high specificity. Due to their unique properties, they are considered promising recognition ligands for the early detection of cancer by liquid biopsy. A variety of circulating targets have been isolated with high affinity and specificity by facile modification and affinity regulation of the aptamers. In this review, we discuss recent progress in aptamer-mediated liquid biopsy for cancer detection, its associated challenges, and its future potential for clinical applications.https://www.mdpi.com/1422-0067/22/11/5601early cancer detectioncirculating biomarkersliquid biopsyaptamerextracellular vesiclesnon-invasive diagnosis
collection DOAJ
language English
format Article
sources DOAJ
author Dhruvajyoti Roy
Andreas Pascher
Mazen A. Juratli
Judith C. Sporn
spellingShingle Dhruvajyoti Roy
Andreas Pascher
Mazen A. Juratli
Judith C. Sporn
The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
International Journal of Molecular Sciences
early cancer detection
circulating biomarkers
liquid biopsy
aptamer
extracellular vesicles
non-invasive diagnosis
author_facet Dhruvajyoti Roy
Andreas Pascher
Mazen A. Juratli
Judith C. Sporn
author_sort Dhruvajyoti Roy
title The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
title_short The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
title_full The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
title_fullStr The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
title_full_unstemmed The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
title_sort potential of aptamer-mediated liquid biopsy for early detection of cancer
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-05-01
description The early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuously monitor disease progression and treatment efficacy. Various methods have been implemented to isolate and purify bio-analytes in liquid biopsy specimens. Aptamers are short oligonucleotides consisting of either DNA or RNA that are capable of binding to target molecules with high specificity. Due to their unique properties, they are considered promising recognition ligands for the early detection of cancer by liquid biopsy. A variety of circulating targets have been isolated with high affinity and specificity by facile modification and affinity regulation of the aptamers. In this review, we discuss recent progress in aptamer-mediated liquid biopsy for cancer detection, its associated challenges, and its future potential for clinical applications.
topic early cancer detection
circulating biomarkers
liquid biopsy
aptamer
extracellular vesicles
non-invasive diagnosis
url https://www.mdpi.com/1422-0067/22/11/5601
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