The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer
The early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuou...
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doaj-7aaaab63f694464e85a2059bfae24ea72021-06-01T01:04:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225601560110.3390/ijms22115601The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of CancerDhruvajyoti Roy0Andreas Pascher1Mazen A. Juratli2Judith C. Sporn3Helio Health, Irvine, CA 92618, USADepartment of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, GermanyDepartment of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, GermanyDepartment of General, Visceral and Transplant Surgery, University Hospital Münster, 48149 Münster, GermanyThe early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuously monitor disease progression and treatment efficacy. Various methods have been implemented to isolate and purify bio-analytes in liquid biopsy specimens. Aptamers are short oligonucleotides consisting of either DNA or RNA that are capable of binding to target molecules with high specificity. Due to their unique properties, they are considered promising recognition ligands for the early detection of cancer by liquid biopsy. A variety of circulating targets have been isolated with high affinity and specificity by facile modification and affinity regulation of the aptamers. In this review, we discuss recent progress in aptamer-mediated liquid biopsy for cancer detection, its associated challenges, and its future potential for clinical applications.https://www.mdpi.com/1422-0067/22/11/5601early cancer detectioncirculating biomarkersliquid biopsyaptamerextracellular vesiclesnon-invasive diagnosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dhruvajyoti Roy Andreas Pascher Mazen A. Juratli Judith C. Sporn |
spellingShingle |
Dhruvajyoti Roy Andreas Pascher Mazen A. Juratli Judith C. Sporn The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer International Journal of Molecular Sciences early cancer detection circulating biomarkers liquid biopsy aptamer extracellular vesicles non-invasive diagnosis |
author_facet |
Dhruvajyoti Roy Andreas Pascher Mazen A. Juratli Judith C. Sporn |
author_sort |
Dhruvajyoti Roy |
title |
The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer |
title_short |
The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer |
title_full |
The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer |
title_fullStr |
The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer |
title_full_unstemmed |
The Potential of Aptamer-Mediated Liquid Biopsy for Early Detection of Cancer |
title_sort |
potential of aptamer-mediated liquid biopsy for early detection of cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-05-01 |
description |
The early detection of cancer favors a greater chance of curative treatment and long-term survival. Exciting new technologies have been developed that can help to catch the disease early. Liquid biopsy is a promising non-invasive tool to detect cancer, even at an early stage, as well as to continuously monitor disease progression and treatment efficacy. Various methods have been implemented to isolate and purify bio-analytes in liquid biopsy specimens. Aptamers are short oligonucleotides consisting of either DNA or RNA that are capable of binding to target molecules with high specificity. Due to their unique properties, they are considered promising recognition ligands for the early detection of cancer by liquid biopsy. A variety of circulating targets have been isolated with high affinity and specificity by facile modification and affinity regulation of the aptamers. In this review, we discuss recent progress in aptamer-mediated liquid biopsy for cancer detection, its associated challenges, and its future potential for clinical applications. |
topic |
early cancer detection circulating biomarkers liquid biopsy aptamer extracellular vesicles non-invasive diagnosis |
url |
https://www.mdpi.com/1422-0067/22/11/5601 |
work_keys_str_mv |
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