Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients

Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients

<p>Abstract</p> <p>Background</p> <p>Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune-compromised states. SMX-induced hypersensitivity is an idiosyncratic cutaneous drug reaction with genetic...

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Bibliographic Details
Main Authors: Wang Danxin, Curtis Amanda, Papp Audrey C, Koletar Susan L, Para Michael F
Format: Article
Language:English
Published: BMC 2012-07-01
Series:BMC Medical Genomics
Subjects:
Idiosyncratic drug reaction
Sulfamethoxazole
Hypersensitivity
Glutamate cysteine ligase catalytic subunit (GCLC)
Association
HIV/AIDS
Online Access:http://www.biomedcentral.com/1755-8794/5/32

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