Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]

<strong>BACKGROUND</strong>: Yearly, 200–300 new spinal cord injuries (SCI) happen in the Czech Republic. Some of these patients suffer from autonomic disturbances, especially concerning their cardiovascular and genito-urinary systems. Autonomic disturbances markedly decrease quality of...

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Main Authors: Milada Betlachová, Amr Zaatar, Jaroslav Opavský, Petr Uhlíř
Format: Article
Language:English
Published: Palacky University 2010-06-01
Series:Acta Universitatis Palackianae Olomucensis. Gymnica
Subjects:
Online Access:http://www.gymnica.upol.cz/index.php/gymnica/article/view/213
id doaj-7aa530e2d2eb4d5a87fc3f489ff7d851
record_format Article
collection DOAJ
language English
format Article
sources DOAJ
author Milada Betlachová
Amr Zaatar
Jaroslav Opavský
Petr Uhlíř
spellingShingle Milada Betlachová
Amr Zaatar
Jaroslav Opavský
Petr Uhlíř
Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
Acta Universitatis Palackianae Olomucensis. Gymnica
spinal cord injury
spectral analysis
heart rate variability
autonomic nervous system
author_facet Milada Betlachová
Amr Zaatar
Jaroslav Opavský
Petr Uhlíř
author_sort Milada Betlachová
title Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
title_short Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
title_full Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
title_fullStr Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
title_full_unstemmed Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
title_sort spectral analysis of heart rate variability in patients with spinal cord injury [spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]
publisher Palacky University
series Acta Universitatis Palackianae Olomucensis. Gymnica
issn 1212-1185
1213-8312
publishDate 2010-06-01
description <strong>BACKGROUND</strong>: Yearly, 200–300 new spinal cord injuries (SCI) happen in the Czech Republic. Some of these patients suffer from autonomic disturbances, especially concerning their cardiovascular and genito-urinary systems. Autonomic disturbances markedly decrease quality of life in patients with SCI. It is important to assess the severity of the autonomic nervous system (ANS) involvement in these subjects. <strong>OBJECTIVE</strong>: The main aim of this study was to assess the spectral analysis of heart rate variability as a marker of cardiovascular autonomic regulation in patients with spinal cord injury and to compare it with findings in healthy controls. <strong>METHODS</strong>: Ten paraplegics (with a mean age of 53.1 ± 15.8 years, seven males and three females) participated in this study. There were five patients with incomplete and five patients with complete spinal cord injury. The ASIA – American Spinal Injury Association, the modified Ashworth scale and the Questionnaire on Autonomic Functions were used. Autonomic reactivity was evaluated by means of the spectral analysis of heart rate variability (SAHRV) method (short-term registration) using the supine-sitting-supine test. Diagnostic system VarCor PF7, which is an innovation of the VarCor PF6 system, was used. Twenty four healthy subjects (with a mean age of 51.9 ± 9.4 years) were enrolled as a control group. <strong>RESULTS</strong>: A marked decrease of the reactivity of the autonomic nervous system as a response to orthostatic changes was found in patients after SCI (paraplegics). In particular, characteristic responses of low frequency (LF) and high frequency (HF) spectral components during the body position changes were suppressed in these patients in comparison with healthy controls. Furthermore, a significant decrease in the spectral power of the LF and HF components was found in patients after SCI. The value of the spectrum's total power (TP) was significantly lower in the group of paraplegics in comparison with healthy volunteers, both in the first and in the repeated supine positions. A significant degree of orthostatic hypotension was registered only in two paraplegics in a sitting position. A lower increase in the LF/HF ratio was registered in a sitting position in a group of paraplegics in comparison with healthy subjects. <strong>CONCLUSIONS</strong>: A decrease in the reactivity of the autonomic nervous system to orthostatic changes, which evidences disturbances of cardiovascular regulation, was found in patients after spinal cord injury (paraplegics). The reduction of the low-frequency component (LF) of the spectral analysis of heart rate variability reflects a lowered sympathetic activity in these patients in a sitting position. It reflects ortostatic disturbances in situations with body position changes associated with a modified orthostatic load. Blood pressure measurement and SAHRV contribute to a more precise assessment of the autonomic dysfunction in patients after SCI.<br>[<strong>V&Yacute;CHODISKA</strong>: Každoročně se v Česk&eacute; republice vyskytne 200&ndash;300 nov&yacute;ch poraněn&iacute; m&iacute;chy (SCI). Někteř&iacute; z těchto pacientů trp&iacute; autonomn&iacute;mi poruchami, jež zasahuj&iacute; zejm&eacute;na jejich kardiovaskul&aacute;rn&iacute; a genitourin&aacute;rn&iacute; syst&eacute;m. Autonomn&iacute; poruchy značně snižuj&iacute; kvalitu života pacientů s SCI. U těchto subjektů je důležit&eacute; posoudit z&aacute;važnost postižen&iacute; autonomn&iacute; nervov&eacute; soustavy (ANS). <strong>C&Iacute;LE</strong>: Hlavn&iacute;m c&iacute;lem t&eacute;to studie bylo posoudit spektr&aacute;ln&iacute; anal&yacute;zu variability srdečn&iacute; frekvence jako indik&aacute;toru kardiovaskul&aacute;rn&iacute; autonomn&iacute; regulace u pacientů s poraněn&iacute;m m&iacute;chy a porovnat ji s n&aacute;lezy zji&scaron;těn&yacute;mi u zdrav&yacute;ch kontroln&iacute;ch jedinců. <strong>METODIKA</strong>: T&eacute;to studie se z&uacute;častnili paraplegici (průměrn&yacute; věk 53,1 &plusmn; 15,8 let, sedm mužů a tři ženy). U pěti z nich byla m&iacute;cha poraněna č&aacute;stečně a u zbyl&yacute;ch pěti zcela. Byla použita klasifikace ASIA (American Spinal Injury Association), modifikovan&aacute; Ashworthova stupnice a Dotazn&iacute;k autonomn&iacute;ch funkc&iacute;. Autonomn&iacute; reaktivita byla hodnocena pomoc&iacute; metody spektr&aacute;ln&iacute; anal&yacute;zy variability srdečn&iacute; frekvence (SAHRV; kr&aacute;tkodob&aacute; registrace) za použit&iacute; testu leh-sed-leh (su pine-sitting-supine). Byl použit diagnostick&yacute; syst&eacute;m VarCor PF7, což je inovace syst&eacute;mu VarCor PF6. Kontroln&iacute; skupinu tvořilo dvacet čtyři subjektů (průměrn&yacute; věk 51,9 &plusmn; 9,4 roku). <strong>V&Yacute;SLEDKY</strong>: U pacientů po SCI (paraplegiků) byl v r&aacute;mci reakce na ortostatick&eacute; změny zji&scaron;těn v&yacute;razn&yacute; pokles reaktivity autonomn&iacute; nervov&eacute; soustavy. Ve srovn&aacute;n&iacute; se zdrav&yacute;mi kontroln&iacute;mi jedinci byly u těchto pacientů během změn pozice těla potlačeny zejm&eacute;na charakteristick&eacute; reakce n&iacute;zkofrekvenčn&iacute;ch (LF) a vysokofrekvenč n&iacute;ch (HF) spektr&aacute;ln&iacute;ch složek. Nav&iacute;c byl u těchto pacientů zaznamen&aacute;n v&yacute;znamn&yacute; pokles spektr&aacute;ln&iacute;ho v&yacute;konu u LF a HF složek. Hodnota celkov&eacute;ho v&yacute;konu (TP) spektra byla v&yacute;razně niž&scaron;&iacute; ve skupině paraplegiků ve srovn&aacute;n&iacute; se zdrav&yacute;mi dobrovoln&iacute;ky, a to jak při prvn&iacute; pozici vleže, tak i při opakovan&yacute;ch pozic&iacute;ch vleže. V&yacute;znamn&aacute; m&iacute;ra ortostatick&eacute; hypotenze byla zaznamen&aacute;na pouze u dvou paraplegiků v poloze vsedě. Men&scaron;&iacute; zv&yacute;&scaron;en&iacute; poměru LF/HF bylo zaznamen&aacute;no v poloze vsedě ve skupině paraplegiků ve srovn&aacute;n&iacute; se zdrav&yacute;mi jedinci. <strong>Z&Aacute;VĚRY</strong>: U pacientů s poraněn&iacute;m m&iacute;chy (paraplegiků) byl zji&scaron;těn pokles reaktivity autonomn&iacute; nervov&eacute; soustavy na ortostatick&eacute; změny, což dokazuje poruchy kardiovaskul&aacute;rn&iacute; regulace. Sn&iacute;žen&iacute; n&iacute;zkofrekvenčn&iacute; (LF) složky spektr&aacute;ln&iacute; anal&yacute;zy variability srdečn&iacute; frekvence u těchto pacientů reflektuje sn&iacute;ženou sympatickou aktivitu v poloze vsedě. Odr&aacute;ž&iacute; ortostatick&eacute; poruchy v situac&iacute;ch, kdy se měn&iacute; poloha těla, což je spojeno se změnou ortostatick&eacute;ho zat&iacute;žen&iacute;. Přesněj&scaron;&iacute; hodnocen&iacute; autonomn&iacute; dysfunkce u pacientů po SCI je podpořeno měřen&iacute;m krevn&iacute;ho tlaku a SAHRV.]
topic spinal cord injury
spectral analysis
heart rate variability
autonomic nervous system
url http://www.gymnica.upol.cz/index.php/gymnica/article/view/213
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spelling doaj-7aa530e2d2eb4d5a87fc3f489ff7d8512020-11-25T01:48:40ZengPalacky UniversityActa Universitatis Palackianae Olomucensis. Gymnica1212-11851213-83122010-06-014025562Spectral analysis of heart rate variability in patients with spinal cord injury [Spektrální analýza variability srdeční frekvence u pacientů s poraněním míchy]Milada BetlachováAmr ZaatarJaroslav OpavskýPetr Uhlíř<strong>BACKGROUND</strong>: Yearly, 200–300 new spinal cord injuries (SCI) happen in the Czech Republic. Some of these patients suffer from autonomic disturbances, especially concerning their cardiovascular and genito-urinary systems. Autonomic disturbances markedly decrease quality of life in patients with SCI. It is important to assess the severity of the autonomic nervous system (ANS) involvement in these subjects. <strong>OBJECTIVE</strong>: The main aim of this study was to assess the spectral analysis of heart rate variability as a marker of cardiovascular autonomic regulation in patients with spinal cord injury and to compare it with findings in healthy controls. <strong>METHODS</strong>: Ten paraplegics (with a mean age of 53.1 ± 15.8 years, seven males and three females) participated in this study. There were five patients with incomplete and five patients with complete spinal cord injury. The ASIA – American Spinal Injury Association, the modified Ashworth scale and the Questionnaire on Autonomic Functions were used. Autonomic reactivity was evaluated by means of the spectral analysis of heart rate variability (SAHRV) method (short-term registration) using the supine-sitting-supine test. Diagnostic system VarCor PF7, which is an innovation of the VarCor PF6 system, was used. Twenty four healthy subjects (with a mean age of 51.9 ± 9.4 years) were enrolled as a control group. <strong>RESULTS</strong>: A marked decrease of the reactivity of the autonomic nervous system as a response to orthostatic changes was found in patients after SCI (paraplegics). In particular, characteristic responses of low frequency (LF) and high frequency (HF) spectral components during the body position changes were suppressed in these patients in comparison with healthy controls. Furthermore, a significant decrease in the spectral power of the LF and HF components was found in patients after SCI. The value of the spectrum's total power (TP) was significantly lower in the group of paraplegics in comparison with healthy volunteers, both in the first and in the repeated supine positions. A significant degree of orthostatic hypotension was registered only in two paraplegics in a sitting position. A lower increase in the LF/HF ratio was registered in a sitting position in a group of paraplegics in comparison with healthy subjects. <strong>CONCLUSIONS</strong>: A decrease in the reactivity of the autonomic nervous system to orthostatic changes, which evidences disturbances of cardiovascular regulation, was found in patients after spinal cord injury (paraplegics). The reduction of the low-frequency component (LF) of the spectral analysis of heart rate variability reflects a lowered sympathetic activity in these patients in a sitting position. It reflects ortostatic disturbances in situations with body position changes associated with a modified orthostatic load. Blood pressure measurement and SAHRV contribute to a more precise assessment of the autonomic dysfunction in patients after SCI.<br>[<strong>V&Yacute;CHODISKA</strong>: Každoročně se v Česk&eacute; republice vyskytne 200&ndash;300 nov&yacute;ch poraněn&iacute; m&iacute;chy (SCI). Někteř&iacute; z těchto pacientů trp&iacute; autonomn&iacute;mi poruchami, jež zasahuj&iacute; zejm&eacute;na jejich kardiovaskul&aacute;rn&iacute; a genitourin&aacute;rn&iacute; syst&eacute;m. Autonomn&iacute; poruchy značně snižuj&iacute; kvalitu života pacientů s SCI. U těchto subjektů je důležit&eacute; posoudit z&aacute;važnost postižen&iacute; autonomn&iacute; nervov&eacute; soustavy (ANS). <strong>C&Iacute;LE</strong>: Hlavn&iacute;m c&iacute;lem t&eacute;to studie bylo posoudit spektr&aacute;ln&iacute; anal&yacute;zu variability srdečn&iacute; frekvence jako indik&aacute;toru kardiovaskul&aacute;rn&iacute; autonomn&iacute; regulace u pacientů s poraněn&iacute;m m&iacute;chy a porovnat ji s n&aacute;lezy zji&scaron;těn&yacute;mi u zdrav&yacute;ch kontroln&iacute;ch jedinců. <strong>METODIKA</strong>: T&eacute;to studie se z&uacute;častnili paraplegici (průměrn&yacute; věk 53,1 &plusmn; 15,8 let, sedm mužů a tři ženy). U pěti z nich byla m&iacute;cha poraněna č&aacute;stečně a u zbyl&yacute;ch pěti zcela. Byla použita klasifikace ASIA (American Spinal Injury Association), modifikovan&aacute; Ashworthova stupnice a Dotazn&iacute;k autonomn&iacute;ch funkc&iacute;. Autonomn&iacute; reaktivita byla hodnocena pomoc&iacute; metody spektr&aacute;ln&iacute; anal&yacute;zy variability srdečn&iacute; frekvence (SAHRV; kr&aacute;tkodob&aacute; registrace) za použit&iacute; testu leh-sed-leh (su pine-sitting-supine). Byl použit diagnostick&yacute; syst&eacute;m VarCor PF7, což je inovace syst&eacute;mu VarCor PF6. Kontroln&iacute; skupinu tvořilo dvacet čtyři subjektů (průměrn&yacute; věk 51,9 &plusmn; 9,4 roku). <strong>V&Yacute;SLEDKY</strong>: U pacientů po SCI (paraplegiků) byl v r&aacute;mci reakce na ortostatick&eacute; změny zji&scaron;těn v&yacute;razn&yacute; pokles reaktivity autonomn&iacute; nervov&eacute; soustavy. Ve srovn&aacute;n&iacute; se zdrav&yacute;mi kontroln&iacute;mi jedinci byly u těchto pacientů během změn pozice těla potlačeny zejm&eacute;na charakteristick&eacute; reakce n&iacute;zkofrekvenčn&iacute;ch (LF) a vysokofrekvenč n&iacute;ch (HF) spektr&aacute;ln&iacute;ch složek. Nav&iacute;c byl u těchto pacientů zaznamen&aacute;n v&yacute;znamn&yacute; pokles spektr&aacute;ln&iacute;ho v&yacute;konu u LF a HF složek. Hodnota celkov&eacute;ho v&yacute;konu (TP) spektra byla v&yacute;razně niž&scaron;&iacute; ve skupině paraplegiků ve srovn&aacute;n&iacute; se zdrav&yacute;mi dobrovoln&iacute;ky, a to jak při prvn&iacute; pozici vleže, tak i při opakovan&yacute;ch pozic&iacute;ch vleže. V&yacute;znamn&aacute; m&iacute;ra ortostatick&eacute; hypotenze byla zaznamen&aacute;na pouze u dvou paraplegiků v poloze vsedě. Men&scaron;&iacute; zv&yacute;&scaron;en&iacute; poměru LF/HF bylo zaznamen&aacute;no v poloze vsedě ve skupině paraplegiků ve srovn&aacute;n&iacute; se zdrav&yacute;mi jedinci. <strong>Z&Aacute;VĚRY</strong>: U pacientů s poraněn&iacute;m m&iacute;chy (paraplegiků) byl zji&scaron;těn pokles reaktivity autonomn&iacute; nervov&eacute; soustavy na ortostatick&eacute; změny, což dokazuje poruchy kardiovaskul&aacute;rn&iacute; regulace. Sn&iacute;žen&iacute; n&iacute;zkofrekvenčn&iacute; (LF) složky spektr&aacute;ln&iacute; anal&yacute;zy variability srdečn&iacute; frekvence u těchto pacientů reflektuje sn&iacute;ženou sympatickou aktivitu v poloze vsedě. Odr&aacute;ž&iacute; ortostatick&eacute; poruchy v situac&iacute;ch, kdy se měn&iacute; poloha těla, což je spojeno se změnou ortostatick&eacute;ho zat&iacute;žen&iacute;. Přesněj&scaron;&iacute; hodnocen&iacute; autonomn&iacute; dysfunkce u pacientů po SCI je podpořeno měřen&iacute;m krevn&iacute;ho tlaku a SAHRV.]http://www.gymnica.upol.cz/index.php/gymnica/article/view/213spinal cord injuryspectral analysisheart rate variabilityautonomic nervous system