Simultaneous Determination by Gas Chromatography of Lindane and Carbaryl in Combined Formulations
A gas chromatographic method developed and validated for simultaneous determination of lindane and carbaryl for quality evaluation of lindane-carbaryl granule, using a glass capillary HP5 column (30 m x 0.32 mm; 0.25 μm), temperature programming with flame ionization detector and dibutylphthalate as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/195495 |
| Summary: | A gas chromatographic method developed and validated for simultaneous determination of lindane and carbaryl for quality evaluation of lindane-carbaryl granule, using a glass capillary HP5 column (30 m x 0.32 mm; 0.25 μm), temperature programming with flame ionization detector and dibutylphthalate as an internal standard. The calibration graphs were found linear in the concentration range of 1 μg/mL to 1000 μg/mL for both lindane and carbaryl with correlation coefficient of 0.999 and 0.999 respectively and co-efficient of variation for intra-day and inter-day repeatability studies at different concentration levels was found to be less than 2%. The accuracy of method ranges between 98.5% to 100.8%. Specificity and robustness were also within the acceptable range. The method is highly sensitive with LOD and LOQ as 0.5 and 2 μg/mL for lindane and carbaryl respectively. The method has been tried on several formulations of lindane-carbaryl granules for quality control and has been found to be applicable. |
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| ISSN: | 0973-4945 2090-9810 |