p53 activation by knockdown technologies.

p53 activation by knockdown technologies.

Morpholino phosphorodiamidate antisense oligonucleotides (MOs) and short interfering RNAs (siRNAs) are commonly used platforms to study gene function by sequence-specific knockdown. Both technologies, however, can elicit undesirable off-target effects. We have used several model genes to study these...

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Bibliographic Details
Main Authors: Mara E Robu, Jon D Larson, Aidas Nasevicius, Soraya Beiraghi, Charles Brenner, Steven A Farber, Stephen C Ekker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1877875?pdf=render

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