Population Pharmacokinetic Study of Cefazolin Used Prophylactically in Canine Surgery for Susceptibility Testing Breakpoint Determination

Population Pharmacokinetic Study of Cefazolin Used Prophylactically in Canine Surgery for Susceptibility Testing Breakpoint Determination

This study aimed to determine the population pharmacokinetic (Pop PK) parameters of cefazolin administered prophylactically at 25 mg/kg intravenously (IV) 30 min before surgery in a canine population of 78 dogs and assess whether covariates, such as sex, age, body weight (BW), breed, health status,...

Full description

Bibliographic Details
Main Authors: Petra Cagnardi, Federica Di Cesare, Pierre-Louis Toutain, Alain Bousquet-Mélou, Giuliano Ravasio, Roberto Villa
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
cefazolin
dog
prophylactic administration
surgery
population pharmacokinetics
PK/PD cut off value
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01137/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01137/full

Similar Items