Recovery of <i>Saccharomyces cerevisiae</i> CNCM I-3856 in Vaginal Samples of Healthy Women after Oral Administration

Bacterial vaginosis and vulvovaginal candidiasis are common causes of impaired health and quality of life for women. Although antimicrobial agents remain the main strategy for the treatment of vaginal infections, their repeated use involves high rates of resistance and recurrence. Alternative approa...

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Bibliographic Details
Main Authors: Amelie Decherf, Elodie Dehay, Mickaël Boyer, Mathieu Clément-Ziza, Bertrand Rodriguez, Sophie Legrain-Raspaud
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Nutrients
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Online Access:https://www.mdpi.com/2072-6643/12/8/2211
Description
Summary:Bacterial vaginosis and vulvovaginal candidiasis are common causes of impaired health and quality of life for women. Although antimicrobial agents remain the main strategy for the treatment of vaginal infections, their repeated use involves high rates of resistance and recurrence. Alternative approaches such as probiotics are studied. <i>Saccharomyces cerevisiae</i> CNCM I-3856 already demonstrated beneficial effects in experimental models of vaginal infections. This randomized, double-blind, placebo-controlled clinical study was performed to evaluate the recovery of <i>S. cerevisiae</i> CNCM I-3856 in vaginal samples in healthy women after oral consumption. Sixty healthy women were randomized to receive a daily dose of <i>S. cerevisiae</i> CNCM I-3856 or a placebo for 4 weeks. Subcultures and quantitative polymerase chain reaction (qPCR) were used to detect the strain in vaginal and stool samples. A safety assessment was carried out throughout the study. Fifty-seven women completed the study. Over the 4-week supplementation phase, <i>S. cerevisiae</i> CNCM I-3856 has been detected in the vaginal samples of 21% of women (<i>n</i> = 4/19) in the 500 mg Probiotic group and 16% of women (<i>n</i> = 3/19) in the 1000 mg Probiotic group. The strain was detected in the faeces of 90% of women consuming the probiotic. This is the first clinical study demonstrating the migration of yeast from intestine to vagina where it may exert its benefits.
ISSN:2072-6643