HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level

HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level

Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of...

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Main Authors: Ambreen Ayub, Usman Ali Ashfaq, Asma Haque
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/810461
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spelling doaj-7a50a3b7d00d471a8ae9cb1c04ed49622020-11-24T21:04:03ZengHindawi LimitedBioMed Research International2314-61332314-61412013-01-01201310.1155/2013/810461810461HBV Induced HCC: Major Risk Factors from Genetic to Molecular LevelAmbreen Ayub0Usman Ali Ashfaq1Asma Haque2Department of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Faisalabad 38000, PakistanDepartment of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Faisalabad 38000, PakistanDepartment of Bioinformatics and Biotechnology, Government College University Faisalabad (GCUF), Faisalabad 38000, PakistanHepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative.http://dx.doi.org/10.1155/2013/810461
collection DOAJ
language English
format Article
sources DOAJ
author Ambreen Ayub
Usman Ali Ashfaq
Asma Haque
spellingShingle Ambreen Ayub
Usman Ali Ashfaq
Asma Haque
HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
BioMed Research International
author_facet Ambreen Ayub
Usman Ali Ashfaq
Asma Haque
author_sort Ambreen Ayub
title HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_short HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_full HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_fullStr HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_full_unstemmed HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
title_sort hbv induced hcc: major risk factors from genetic to molecular level
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2013-01-01
description Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative.
url http://dx.doi.org/10.1155/2013/810461
work_keys_str_mv AT ambreenayub hbvinducedhccmajorriskfactorsfromgenetictomolecularlevel
AT usmanaliashfaq hbvinducedhccmajorriskfactorsfromgenetictomolecularlevel
AT asmahaque hbvinducedhccmajorriskfactorsfromgenetictomolecularlevel
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