Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear

Blood clotting is a complex process involving platelet adhesion and clot stiffening. Here the authors present a microfluidic system to recapitulate the dynamic changes in clot mechanics under physiological shear.

Bibliographic Details
Main Authors: Zhaowei Chen, Jiankai Lu, Changjie Zhang, Isaac Hsia, Xinheng Yu, Leo Marecki, Eric Marecki, Mohammadnabi Asmani, Shilpa Jain, Sriram Neelamegham, Ruogang Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10067-6
Description
Summary:Blood clotting is a complex process involving platelet adhesion and clot stiffening. Here the authors present a microfluidic system to recapitulate the dynamic changes in clot mechanics under physiological shear.
ISSN:2041-1723