Clinical significance of coagulation function and plasma cTnI, HCY, PCT levels in the severity and prognosis in patients with acute craniocerebral injury

• Main Authors: Jun-Qing Shao, Xiao-Fei Chen, Yi Li, Xiang-You Mo, Shun-Jiang Lin, Jun-Lin Mo
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-09-01
• Series: Journal of Hainan Medical University
• Subjects: Acute Craniocerebral injury; Coagulation function; CTnI; HCY; PCT; Prognosis
• Online Access: http://www.hnykdxxb.com/PDF/201717/30.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To investigate the relationship between changes of coagulation function and plasma cTnI, HCY, PCT levels and cerebral trauma severity and prognosis in patients with acute craniocerebral injury. Method: A total of 80 patients with acute craniocerebral injury treated in our hospital from May 2014 to May 2017 were selected as the observation group and divided into 3 groups according to the admission GCS score: mild (27 cases), moderate (28 cases) and severe group (25 cases). 40 healthy volunteers were selected as the control group. The index of blood coagulation (APTT, PT, Fib, TT, DD) and the levels of cTnI, HCY, PCT in observation group after injury and in control group were detected and analysed comparatively. After 1 months of treatment, 80 patients were divided into the good prognosis group (54 cases) and poor prognosis group (26 cases) according to the GOS score and the levels of the parameters above were detected. Results: (1) The PT, APTT, TT and DD levels of mild, moderate and severe acute craniocerebral injury groups were higher than those of the control group, but the level of Fib was lower than that of the control group, and there was also a significant difference between any two groups respectively. (2) The cTnI, HCY and PCT levels of mild, moderate and severe acute craniocerebral injury groups were higher than those of the control group, and there was also a significant difference between any two groups respectively. (3) The indexes of PT, APTT and DD in the good prognosis group were lower than those in the poor prognosis group, while the Fib level was higher significantly. (4) The levels of cTnI, HCY and PCT in the good prognosis group were significantly lower than those in the poor prognosis group. Conclusion: The levels of coagulation function and plasma cTnI, HCY, PCT in acute craniocerebral injury patients were correlated positively with the severity and prognosis of patients with craniocerebral injury