Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

Paeonol Suppresses Chondrosarcoma Metastasis through Up-Regulation of miR-141 by Modulating PKCδ and c-Src Signaling Pathway

Chondrosarcoma, a primary malignant bone cancer, has potential for local invasion and distant metastasis, especially to the lungs. Patients diagnosed with it show poor prognosis. Paeonol (2'-hydroxy-4'-methoxyacetophenone), the main active compound of traditional Chinese remedy Paeonia lac...

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Bibliographic Details
Main Authors: Chi-Ting Horng, Po-Chuen Shieh, Tzu-Wei Tan, Wei-Hung Yang, Chih-Hsin Tang
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:International Journal of Molecular Sciences
Subjects:
paeonol
chondrosarcoma
miR-141
metastasis
Online Access:http://www.mdpi.com/1422-0067/15/7/11760

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