Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation

Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation

Thyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-ce...

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Main Authors: Satoko Oka, Kazuo Ono, Masaharu Nohgawa
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048918300591
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spelling doaj-7a19187bd6a94fed8a13777afca3c0362020-11-25T01:26:21ZengElsevierLeukemia Research Reports2213-04892019-01-011157Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantationSatoko Oka0Kazuo Ono1Masaharu Nohgawa2Division of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, Japan; Corresponding author.Division of Pathology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, JapanDivision of Hematology, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Wakayama, JapanThyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroidism. The long-term monitoring of thyroid function, T-cell populations, and cytomegalovirus after HSCT is important. Keywords: Thyroid disease, Transplantation, Autologous, Autoimmune, Cytomegalovirushttp://www.sciencedirect.com/science/article/pii/S2213048918300591
collection DOAJ
language English
format Article
sources DOAJ
author Satoko Oka
Kazuo Ono
Masaharu Nohgawa
spellingShingle Satoko Oka
Kazuo Ono
Masaharu Nohgawa
Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
Leukemia Research Reports
author_facet Satoko Oka
Kazuo Ono
Masaharu Nohgawa
author_sort Satoko Oka
title Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
title_short Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
title_full Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
title_fullStr Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
title_full_unstemmed Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
title_sort cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation
publisher Elsevier
series Leukemia Research Reports
issn 2213-0489
publishDate 2019-01-01
description Thyroid dysfunction is an important issue in patients receiving autologous and allogenic hematopoietic stem cell transplantation (HSCT). However, the exact mechanisms underlying thyrotoxicosis secondary to HSCT remain unclear. The present case exhibited a reversed imbalance in helper/suppressor T-cell populations and B-cell dysregulation for a long time after transplantation, and the reactivation of cytomegalovirus may have been associated with the development of clinical hyperthyroidism. The long-term monitoring of thyroid function, T-cell populations, and cytomegalovirus after HSCT is important. Keywords: Thyroid disease, Transplantation, Autologous, Autoimmune, Cytomegalovirus
url http://www.sciencedirect.com/science/article/pii/S2213048918300591
work_keys_str_mv AT satokooka cytomegalovirusreactivationtriggersthelateonsetofhyperthyroidismafterautologousperipheralbloodtransplantation
AT kazuoono cytomegalovirusreactivationtriggersthelateonsetofhyperthyroidismafterautologousperipheralbloodtransplantation
AT masaharunohgawa cytomegalovirusreactivationtriggersthelateonsetofhyperthyroidismafterautologousperipheralbloodtransplantation
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