Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some circumstances, autophagy leads to cell death. Thereby, autophagy can serve as t...
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doaj-7a04aebf49384c008e75046be0e0ed482020-11-24T21:03:50ZengHindawi LimitedInternational Journal of Breast Cancer2090-31892011-01-01201110.4061/2011/595092595092Autophagy: Friend or Foe in Breast Cancer Development, Progression, and TreatmentDamian E. Berardi0Paola B. Campodónico1Maria Ines Díaz Bessone2Alejandro J. Urtreger3Laura B. Todaro4Research Area, Institute of Oncology “Angel H. Roffo”, University of Buenos Aires, C1417DTB Buenos Aires, ArgentinaResearch Area, Institute of Oncology “Angel H. Roffo”, University of Buenos Aires, C1417DTB Buenos Aires, ArgentinaResearch Area, Institute of Oncology “Angel H. Roffo”, University of Buenos Aires, C1417DTB Buenos Aires, ArgentinaResearch Area, Institute of Oncology “Angel H. Roffo”, University of Buenos Aires, C1417DTB Buenos Aires, ArgentinaResearch Area, Institute of Oncology “Angel H. Roffo”, University of Buenos Aires, C1417DTB Buenos Aires, ArgentinaAutophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some circumstances, autophagy leads to cell death. Thereby, autophagy can serve as tumor suppressor, as the reduction in autophagic capacity causes malignant transformation and spontaneous tumors. On the other hand, this process also functions as a protective cell-survival mechanism against environmental stress causing resistance to antineoplastic therapies. Although autophagy inhibition, combined with anticancer agents, could be therapeutically beneficial in some cases, autophagy induction by itself could lead to cell death in some apoptosis-resistant cancers, indicating that autophagy induction may also be used as a therapy. This paper summarizes the most important findings described in the literature about autophagy and also discusses the importance of this process in clinical settings.http://dx.doi.org/10.4061/2011/595092 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Damian E. Berardi Paola B. Campodónico Maria Ines Díaz Bessone Alejandro J. Urtreger Laura B. Todaro |
spellingShingle |
Damian E. Berardi Paola B. Campodónico Maria Ines Díaz Bessone Alejandro J. Urtreger Laura B. Todaro Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment International Journal of Breast Cancer |
author_facet |
Damian E. Berardi Paola B. Campodónico Maria Ines Díaz Bessone Alejandro J. Urtreger Laura B. Todaro |
author_sort |
Damian E. Berardi |
title |
Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment |
title_short |
Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment |
title_full |
Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment |
title_fullStr |
Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment |
title_full_unstemmed |
Autophagy: Friend or Foe in Breast Cancer Development, Progression, and Treatment |
title_sort |
autophagy: friend or foe in breast cancer development, progression, and treatment |
publisher |
Hindawi Limited |
series |
International Journal of Breast Cancer |
issn |
2090-3189 |
publishDate |
2011-01-01 |
description |
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some circumstances, autophagy leads to cell death. Thereby, autophagy can serve as tumor suppressor, as the reduction in autophagic capacity causes malignant transformation and spontaneous tumors. On the other hand, this process also functions as a protective cell-survival mechanism against environmental stress causing resistance to antineoplastic therapies.
Although autophagy inhibition, combined with anticancer agents, could be therapeutically beneficial in some cases, autophagy induction by itself could lead to cell death in some apoptosis-resistant cancers, indicating that autophagy induction may also be used as a therapy. This paper summarizes the most important findings described in the literature about autophagy and also discusses the importance of this process in clinical settings. |
url |
http://dx.doi.org/10.4061/2011/595092 |
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