Fermentation, Purification, and Tumor Inhibition of a Disulfide-Stabilized Diabody Against Fibroblast Growth Factor-2

Fermentation, Purification, and Tumor Inhibition of a Disulfide-Stabilized Diabody Against Fibroblast Growth Factor-2

Angiogenesis is considered one of the hallmarks of cancer and plays a critical role in the development of tumor. Fibroblast growth factor 2 (FGF-2) is a member of the FGF family and participates in excessive cancer cell proliferation and tumor angiogenesis. Thus, targeting FGF-2 was considered to be...

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Bibliographic Details
Main Authors: Simin Zhang, Jiahui Huang, Ligang Zhang, Jiangtao Gu, Qifang Song, Yaxiong Cai, Jiangchuan Zhong, Hui Zhong, Yanrui Deng, Wenhui Zhu, Jianfu Zhao, Ning Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
fibroblast growth factor 2
angiogenesis
disulfide-stabilized diabody
melanoma cancer
glioma cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.585457/full

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