Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disease affecting lower motor neurons that is caused by a deficiency in ubiquitously expressed Survival Motor Neuron (SMN) protein. Two mutually exclusive hypotheses have been discussed to explain increased motor neuron vulnerability i...

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Bibliographic Details
Main Authors: Angela Koh, Menachem Viktor Sarusie, Jürgen Ohmer, Utz Fischer, Christoph Winkler, Thorsten Wohland
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
fluorescence correlation spectroscopy
spinal muscular atrophy
survival motion neuron
zebrafish
motor axons
active transport
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.639904/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.639904/full

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