The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila

The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila

fruitless (fru) is an important sex-determinant gene that controls the expression of neuroanatomical sex differences in Drosophila. Here the authors report that a core-promoter factor, TRF2, suppresses a male-type neurite specification through direct interaction with FruBM isoform at the robo1 targe...

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Main Authors: Zahid Sadek Chowdhury, Kosei Sato, Daisuke Yamamoto
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01623-z
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spelling doaj-79f6e07656c84a5899a4df6440d7fe9f2021-05-11T07:27:26ZengNature Publishing GroupNature Communications2041-17232017-11-018111010.1038/s41467-017-01623-zThe core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in DrosophilaZahid Sadek Chowdhury0Kosei Sato1Daisuke Yamamoto2Tohoku University Graduate School of Life SciencesTohoku University Graduate School of Life SciencesTohoku University Graduate School of Life Sciencesfruitless (fru) is an important sex-determinant gene that controls the expression of neuroanatomical sex differences in Drosophila. Here the authors report that a core-promoter factor, TRF2, suppresses a male-type neurite specification through direct interaction with FruBM isoform at the robo1 target gene promoter.https://doi.org/10.1038/s41467-017-01623-z
collection DOAJ
language English
format Article
sources DOAJ
author Zahid Sadek Chowdhury
Kosei Sato
Daisuke Yamamoto
spellingShingle Zahid Sadek Chowdhury
Kosei Sato
Daisuke Yamamoto
The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila
Nature Communications
author_facet Zahid Sadek Chowdhury
Kosei Sato
Daisuke Yamamoto
author_sort Zahid Sadek Chowdhury
title The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila
title_short The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila
title_full The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila
title_fullStr The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila
title_full_unstemmed The core-promoter factor TRF2 mediates a Fruitless action to masculinize neurobehavioral traits in Drosophila
title_sort core-promoter factor trf2 mediates a fruitless action to masculinize neurobehavioral traits in drosophila
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description fruitless (fru) is an important sex-determinant gene that controls the expression of neuroanatomical sex differences in Drosophila. Here the authors report that a core-promoter factor, TRF2, suppresses a male-type neurite specification through direct interaction with FruBM isoform at the robo1 target gene promoter.
url https://doi.org/10.1038/s41467-017-01623-z
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AT daisukeyamamoto thecorepromoterfactortrf2mediatesafruitlessactiontomasculinizeneurobehavioraltraitsindrosophila
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AT koseisato corepromoterfactortrf2mediatesafruitlessactiontomasculinizeneurobehavioraltraitsindrosophila
AT daisukeyamamoto corepromoterfactortrf2mediatesafruitlessactiontomasculinizeneurobehavioraltraitsindrosophila
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