Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1).

Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1).

<h4>Background</h4>In order to identify novel chemical classes of β-secretase (BACE-1) inhibitors, an alternative scoring protocol, Principal Component Analysis (PCA), was proposed to summarize most of the information from the original scoring functions and re-rank the results from the v...

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Bibliographic Details
Main Authors: Shu Liu, Rao Fu, Li-Hua Zhou, Sheng-Ping Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22701601/pdf/?tool=EBI

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